Azaserine resistance in Escherichia coli: chromosomal location of multiple genes
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چکیده
منابع مشابه
Azaserine resistance in Escherichia coli: chromosomal location of multiple genes.
Resistance to azaserine in Escherichia coli is the result of mutations in at least three different loci. All spontaneously arising azaserine-resistant mutants harbor a lesion in the aroP gene. However, a lesion in this gene is not solely responsible for resistance. All spontaneously arising intermediate-level azaserine-resistant mutants also harbor a lesion in a gene designated azaA, which lies...
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Azaserine (O-diazoacetyl-L-serine) was first isolated from a crude broth filtrate of Streptomyces fragilis and found to possess marked antitumor activity (Ehrlich et al., 1954; Bartz et al., 1954; Stock et al., 1954). The chemical synthesis of this compound was reported immediately thereafter; the synthetic O-diazoacetyl-L-serine was found to be identical in all physical, chemical, and biologic...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1980
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.143.1.383-388.1980